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Figure 1 Methods of data handling with missing data on progression.

At least nine events are related in assessing PFS: I. Local regional relapse; II. Distant metastases; III. Second primary tumor-same entity; IV. Second primary tumor-other entity; V. *Death related to tumor; VI. *Death related to another tumor; VII. *Tumor independent death; VIII. *Death related to tumor therapy; IX. Lost to Follow-up: Censored. All events marked by * are also covered by OS ( Dodo Bar Or Floral Print Dress Pink And Purple mv0HNzTWPp
) ( Sam Edelman Rachel Straw Fringe Tote Coral Multi ig24RSWBXu
).

Figure 2 All events of OS are covered by PFS; PFS shows additionally the events of tumor control.

To demonstrate the impact of sample size Tumi Mansion Leather Trimmed Nylon Car Bag lOIu3
illustrates calculation for trials where the surplus in overall survival varies. Sample size is calculated by the log rank test (Freedman) under the assumption that in the two groups the hazards are proportional (PASS 11, version 11.0.7, 2011) ( 42 , Brian Dales Short Dresses Ivory PwKgbL5
). Further on, it is assumed that the survival times are exponentially distributed. If the median survival of the control group is 12 months then the 1-year survival rate is 50%. An increase of 10% to a 1-year rate of 55% is equivalent to a survival of 14 months. A rate of 60% corresponds to 16.3 months, 65% to 19.4 months, and 70% to 23.4 months, nearly doubling the survival time. For superiority the one-sided test is used. The power was set to 90% or 80% and α=0.025 or α=0.05. Accrual is 1 : 1 for the two groups. The sample sizes vary between N=4059 and N=151 depending on the power, significance and survival proportion. A small incremental increase in survival time accompanied by small error rates (power and α) leads to a large study population.

Figure 3 Sample size calculation for proportion of 1-year survival of 0.55-0.70 of experimental group versus 1-year survival of 0.5 for controls in a 1:1 recruitment and with power of 80% or 90% and α=0.025 or α=0.05.

The main factor for PFS to predict OS is the duration of PFS ( 43 ). A significant survival gain can be predicted in a trial of 750 patients if 18% of patients responding to treatment. 500 patients are needed if 21% of patients respond and if it is postulated that 30% patients respond, at least 250 patients must be enrolled.

The necessary incremental gain for PFS to predict a survival improvement was a median of 1.7 months for trials with 750 patients, 2.2 months for 500 patients, and 3.3 months for trials with 250 patients. Hence, a significant surplus on PFS can only be predictive for OS if the sample is big enough. Statistically it comes to compare PFS and OS as two failure time distributions in the presence of censoring, where the distribution is shifted due to the different time interval of measurement ( 44 ). Compared to OS in PFS more competing risks are included ( Figure 2 ). PFS as surrogate endpoint for OS can also be investigated by the aid of a stochastic model ( Paule Ka Color Blocked Stretch Sheath Dress Beige Marine JgZsKTU
). The Process was demonstrated theoretically by a statistical OS model with two independent stochastic processes defining an interim and a restart point of progression. Since it has been discovered that the interval after progression to death may have similar distribution for most of the lung cancer trials PFS as a surrogate of OS seem to be reasonable ( Maison Martin Margiela Mm6 By Knee Length Dresses Ivory XxjzRqO9
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). The strongest prediction of PFS for OS results from a high correlation of PFS and OS and a high treatment effect homogeneity ( Figure 4 ).

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C3 Collaborating for Health builds multi-sector C ollaboration to promote 3 behaviour changes:

stopping smoking

improving what we eat and drink

increasing physical activity

to addressthe escalating non-communicable disease (NCD) epidemic.

20 Feb 2018
Sarah Clarke

A free weight management wellbeing app designed by nurses, exclusively for nurses.

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20 Jul 2017
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Our seminars bring globally-renowned experts together with multi-sector UK professionals to discuss innovative approaches to health and prevention.

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20 Jul 2017
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C3 draws on experts from its global network of 2,500+ members and 72 countries. Join our network today!

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Latest Event

We host a range of events, including our Needle amp; Thread Tiled Broderie Anglaise Lace Dress Dust Lavender WgzysoVeyj
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meetings.

The Access to Nutrition Index is the first systematic effort to compare major global food and beverage (FB) manufacturers’ contribution to addressing global nutrition challenges: the good, bad and opportunities for improvement. Join us 17 July to hear how the world's largest FB organisations rate.

Tuesday, 17 July 2018 at 8:30 am (breakfast registration from 8am)

CAN Mezzanine, 7-14 Great Dover Street, London SE1 4YR

LATEST BLOGS

26 Jun 2018
J T Winkler and Tam Fry
Has the Soft Drinks Industry Levy been successful? C3 network members J T Winkler and Tam Fry write about a 'radical change' in a popular, mass-market product. Have we successfully given people economic incentives, and not just moral injunctions?

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14 Jun 2018
Kelly Adam
In 2017, C3 Collaborating for Health was commissioned by the Health Foundation to hold a series of workshops that brought together UK third-sector community-based services that support young people aged 14 to 24.

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10 May 2018
Richard Smith
Progress has stalled over the past few years, but with better messaging, a simplified programme, and increased accountability then 2018 could be the year of NCD. Insights from C3's breakfast seminar with Robert Beaglehole, chair of the Lancet NCD Action Group.

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Need a Comedian or Emcee for your corporate event? We have a variety of comedians from diverse backgrounds to choose from. We specialize in creating comedic material to best suit your event, brand and attendees. We have local, regional and international comedians, some of them are even from Mars.

Mina is an award-winning comedian, emcee, choreographer and Performing Arts Professor. She’s been seen on MTV’s "The Grind" (original cast), Broadway in the smash hit "STOMP" and touring stages around the globe performing stand-up comedy alongside renown comics. She was coined the "UAE’s Queen of Comedy" by Ahlan!, included in Rolling Stones "Funniest people of 2012” and recently filmed her 1 hour Comedy Special “Araby by Nature.” She can currently be seen on Comedy Central Arabia every Sunday night. minaliccione.com

Dubai’s Ali Al Sayed started writing, performing and producing comedy in 2008. His lightning fast wit and rapport with audiences has allowed him to perform in numerous shows at the iconic Comic Strip Live in New York – Headlining in Caroline’s on Broadway, Edinburgh Fringe Festival and hosting MBC Action’s “Desert Force."He can currently be seen on Comedy Central ArabiaSunday evenings co-hostingand was awarded “Comedian of the Year 2016” by Esquire Magazine.He was also named 'One of the Most Influential Comedians in the World' by Toastmaster's International Magazine and included in Rolling Stones "Funniest people of 2012" pick. alsayedcomedy.com

Omar is a British Emirati with a passion for comedy in all its forms. He has been performing comedy professionally with Dubomedy for many years now and is a founding member of the Improv Revolution troupe. He has opened for Dean Edwards from Saturday Night Live , Remy of "Saudis in Audis", performed at the Edinburgh Fringe Festival and recently hosted the grand finale of Kit Kat’s "Comedy Break Show".

Upon moving to Dubai, he decided to take a Dubomedy Stand-up comedy class and the rest is history. He's performed at venues around Dubai, Abu Dhabi, Kuwait and has opened for International comedians including Aron Kader, Dean Obeidallah and Mo Amer. He was awarded first place at the GCC Comedy Competition 2013 as part of the Dubai International Comedy Carnival.

Simeon Goodson is a native of Brooklyn, NY who has been performing in the comedy clubs, bars, and alternative venues of New York City since 2004. He has performed at a variety of world famous venues including Caroline's on Broadway and The Brooklyn Academy of Music. In addition, he has performed across the United States with the "Comedy's Best Kept Secret Tour" and as the opening act on the Hannibal Burress "Comedy Camisado Tour".

and Many more...

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Middle East Event Awards World Equestrian Championship (WEC) Middle East Film Comic Con Reckitt Benckiser Nokia MAC Cosmetics Air Miles MBC Insurex Cisco Pepsi Canon Gitex Kraft Starcom Flash Huawei Technologies Americana – KFC Head and Shoulders Yasalam – Beats by the Beach Dubai Chamber of Commerce AmCham Bee’ah Cadbury Kit Kat Oreo Red Bull Philadelphia Tang Ahlan! Explorer magazine Ski Dubai Toyota Porsche Dettol Barakat Meydan – Dubai races Mercato Mall Festival City Mall Dubai Mall The Address Dubai Marina Movenpick Hotel Rotana Emirates Literature Festival Dubai Ladies Club Mashreq Bank EPPCO / ENOC Swiss Art Gate UAE Al Ain Hospital American University of Sharjah American University of Dubai Sorbonne University Magic lantern Swiss Film Club Children of the Mountain Dubai Summer Surprises (DSS) Dubai Shopping Festival (DSF) SME Magazine PCRF UAE

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Proposal includes key original provisions from SB 822 including banning access fees, maintaining net neutrality at point of interconnection, prohibiting anti-competitive zero-rating products, and joining SB 460 to protect state contracting
July 5, 2018

Sacramento Today, California legislators announced a deal to move forward a proposal to restore Obama-era net neutrality protections that were repealed under Donald Trump’s Federal Communications Commission in early June. Senate Bill 822, introduced by Senator Wiener (D-San Francisco) earlier this year, was amended two weeks ago in the Assembly Communications and Conveyance Committee. Since then, Senators Wiener and de Leon (D-Los Angeles), and Assemblymembers Miguel Santiago (D-Los Angeles) and Rob Bonta (D-Oakland) have worked to craft a strong and enforceable net neutrality proposal.

Today, the legislators announced an agreement on bill language that will ensure California enacts strong, comprehensive, and enforceable net neutrality reflecting what was repealed by the FCC last year. This agreement includes key original concepts in Senator Wiener’s SB 822, including a ban on fees to access internet service provider customers, ensuring net neutrality is not circumvented/evaded at the point of interconnection, and prohibiting discriminatory and anti-competitive zero-rating services. In addition, Senator de Leon’s SB 460 will be amended to ensure that companies entering into state contracts abide by net neutrality principles. As previously announced, SB 822 and SB 460 will be joined so that the two move forward together and complement one another.

These amendments will be formally introduced and put in print in the coming weeks. The bills have until August 31 to be approved by the Legislature.

“After Donald Trump’s FCC obliterated net neutrality, we stepped in to protect California residents and businesses and to ensure an open internet,” said Senator Wiener . “For months, we have worked with a broad coalition to pass strong and enforceable net neutrality protections. As internet service providers and media companies like ATT and Time Warner consolidate, net neutrality is more important than ever. I want to thank my colleagues Senator de Leon, Assemblymember Santiago, and Assemblymember Bonta for working with us to ensure that California moves forward a bill with strong net neutrality proposal that will protect California consumers and set the standard for pro-internet efforts throughout the country.”

"This President and his Administration have made it clear that in today’s America, only some of our freedoms are secure,” said Senator de León. “Here in California, we believe a free and open internet is vital to our democracy and our way of life, which is why we are fighting so hard to preserve Net Neutrality. After weeks of vigorous debate and negotiations, I am proud to stand with my colleagues, Senator Wiener, Assemblymember Santiago, and Assemblymember Bonta to advance the strongest Net Neutrality protections in the nation. If Donald Trump won’t stand up to powerful special interests to protect consumers, the State of California will.”

"In the aftermath of Trump’s destruction of the internet, we are advancing legislation with the strongest net neutrality and consumer protections in the nation. California leads the fight for a free and open internet that doesn’t discriminate or price users orcontent differently” said Assemblymember Santiago .“The fight for social change and progressive values is directly tied to a free and open internet. Citizens United, the Janus decision and now the threat of a Supreme Court nomination under Trump makes this Net Neutrality legislation more important than ever. It is essential to our Democracy and the future of our movement powered by people.”

“Today’s announcement to strengthen SB 822 and SB 460 with the strongest net neutrality laws in the country will ensure California is the leader in the movement for a free and open internet,” said Assemblymember Bonta , who is an original co-author of SB 822. “As the most diverse and innovative state in the nation, it’s imperative we lead by example, remedy the damage caused by the Trump Administration, and protect and stand up for our people. I applaud my co-authors for working through the challenges of this issue and look forward to casting my vote in support.”

The net neutrality proposal put forward in SB 822 and SB 460 stands for the basic proposition that the role of internet service providers (ISPs) is to provide neutral access to the internet, not to pick winners and losers by deciding (based on financial payments or otherwise) which websites or applications will be easy or hard to access, which will have fast or slow access, and which will be blocked entirely.

Under this agreement, SB 822 will contain strong net neutrality protections and prohibit blocking websites, speeding up or slowing down websites or whole classes of applications such as video, and charging websites for access to an ISP’s subscribers or for fast lanes to those subscribers. ISPs will also be prohibited from circumventing these protections at the point where data enters their networks and from charging access fees to reach ISP customers. SB 822 will also ban ISPs from violating net neutrality by not counting the content and websites they own against subscribers’ data caps. This kind of abusive and anti-competitive “zero rating”, which leads to lower data caps for everyone, would be prohibited, while “zero-rating” plans that don’t harm consumers are not banned.

SB 460 will be amended to focus on requiring ISPs that enter into state contracts adhere to net neutrality principles. This provision ensures that public entities only expend taxpayer funds on contracts with ISPs that comply with California’s comprehensive net neutrality protections.

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